Sir Nicholas John White, a distinguished British medical doctor and researcher whose pioneering work in tropical medicine saved millions of lives, passed away on February 1, 2026, at the age of 74. Renowned for his relentless dedication to combating diseases like malaria, Sir Nicholas was a towering figure in global health, leaving an indelible mark on scientific understanding and patient care worldwide.

Born on March 13, 1951, Sir Nicholas pursued his medical education at Guy's Hospital Medical School at King's College London, followed by a residency in internal medicine at various hospitals in London and at the Radcliffe Infirmary in Oxford. His career took a pivotal turn in 1980 when he became a vital part of the scientific collaboration between Mahidol University in Thailand and the University of Oxford, known as the Mahidol Oxford Research Unit. He assumed the directorship of this crucial unit in 1986, expanding its reach to Vietnam and Laos, and establishing research networks that tackled a spectrum of tropical infections.

Sir Nicholas White's most profound impact came through his instrumental role in advocating for and establishing artemisinin-based combination therapy (ACT) as the globally recommended and most effective treatment for malaria caused by the Plasmodium falciparum parasite. His rigorous research and clinical trials demonstrated the effectiveness of artemisinin and the necessity of combining it with other drugs to prevent resistance, fundamentally transforming malaria treatment and prevention strategies, particularly in Africa and Southeast Asia.

His extraordinary contributions were widely recognized through numerous prestigious awards and honors. He was appointed an Officer of the Order of the British Empire (OBE) in 1999, received the GlaxoSmithKline Prize in 2005, and was elected a Fellow of the Royal Society in 2006. Further accolades included the John Dirks Canada Gairdner Global Health Award in 2010 and Thailand's Prince Mahidol Award in 2011. In recognition of his lifetime of service to humanity, he was appointed a Knight Commander of the Order of St Michael and St George (KCMG) in 2017.

Beyond his groundbreaking research, Sir Nicholas was a prolific author, contributing to over 1,300 scientific publications, and served extensively on international advisory bodies, including those of the World Health Organization. He was deeply committed to building sustainable scientific partnerships and empowering local researchers, mentoring hundreds of clinicians and scientists, especially in Southeast Asia. Within Oxford, he was respected for his deep commitment to patient care as a consultant and was known for his unparalleled wit, humor, sage advice, and passion for cricket. His legacy endures through the treatments used globally, the research institutions he helped establish, and the countless lives he touched and saved.